Enpp2^tm1.1Vart
Targeted Allele Detail

Summary

• Symbol: Enpp2^tm1.1Vart
• Name: ectonucleotide pyrophosphatase/phosphodiesterase 2; targeted mutation 1.1, Vassilis Aidinis
• MGI ID: MGI:3790757
• Synonyms: Enpp2ⁿ
• Gene: Enpp2 Location: Chr15:54702297-54816284 bp, - strand Genetic Position: Chr15, 21.6 cM, cytoband D2
• Alliance: Enpp2^tm1.1Vart page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134373
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was derived from Enpp2^tm1Vart, in which a neomycin selection cassette was inserted upstream of exon 1, and the neo cassette and exons 1 and 2 were flanked by loxP sites. Both exons and the selection cassette were then excised by Cre-mediated recombination to generate the knock-out allele. The absence of protein expression was confirmed by immunohistochemistry on E9.5 embryo extracts. (J:134373)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Enpp2 Mutation: 79 strains or lines available

References

• Original: J:134373 Aidinis V, Generation of mice bearing a floxed mutation of Enpp2 (ATX). MGI Direct Data Submission. 2008
• All: 8 reference(s)