Sav1^tm1Dlim
Targeted Allele Detail

Summary

• Symbol: Sav1^tm1Dlim
• Name: salvador family WW domain containing 1; targeted mutation 1, Dae-Sik Lim
• MGI ID: MGI:3790763
• Synonyms: WW45^-
• Gene: Sav1 Location: Chr12:70011786-70033776 bp, - strand Genetic Position: Chr12, 28.94 cM, cytoband C3
• Alliance: Sav1^tm1Dlim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134270
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a puromycin resistance cassette. The absence of protein product was confirmed by western blot analysis on primary mouse embryonic fibroblasts. (J:134270)

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sav1 Mutation: 20 strains or lines available

References

• Original: J:134270 Lee JH, et al., A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008 Apr 23;27(8):1231-42
• All: 4 reference(s)