Rybp^tm1Nisa
Targeted Allele Detail

Summary

• Symbol: Rybp^tm1Nisa
• Name: RING1 and YY1 binding protein; targeted mutation 1, Nicole Schreiber-Agus
• MGI ID: MGI:3790768
• Gene: Rybp Location: Chr6:100205526-100264319 bp, - strand Genetic Position: Chr6, 46.62 cM, cytoband E1
• Alliance: Rybp^tm1Nisa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134591
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 5 were replaced with a EYFP and floxed neo cassette. The floxed neo cassette was removed by transient expression of cre in ES cells. The absence of endogenous protein product was confirmed by western blot analysis on ES cell extracts. The expression of the fusion product was also confirmed by western blot analysis. This is a null allele and a reporter allele. (J:134591)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rybp Mutation: 45 strains or lines available

References

• Original: J:134591 Pirity MK, et al., Rybp/DEDAF is required for early postimplantation and for central nervous system development. Mol Cell Biol. 2005 Aug;25(16):7193-202
• All: 2 reference(s)