Tg(GFAP-B2m)#Mdos
Transgene Detail

Summary

• Symbol: Tg(GFAP-B2m)#Mdos
• Name: transgene insertion #, H Michael Dosch
• MGI ID: MGI:3790770
• Synonyms: GFAP-B2m
• Transgene: Tg(GFAP-B2m)#Mdos Location: unknown
• Alliance: Tg(GFAP-B2m)#Mdos page

Transgene origin

• Strain of Origin: NOD/ShiLtJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(GFAP-B2m)#Mdos expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	B2m (MGI:88127)

• Mutation details: The transgene consists of the human GFAP promoter fused to murine Beta-2 microglobulin, B2m. Six founders resulted from the microinjection of the GFAP-B2m construct into NOD/LtJ oocytes. Lines 9 and 14 were characterized further. Western blot analysis and histological analysis of brain, specifically astrocytes and pancreas, specifically the peri-islet Schwann cells, from transgenic animals confirmed transgene expression. (J:135214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:135214 Tsui H, et al., Targeting of pancreatic glia in type 1 diabetes. Diabetes. 2008 Apr;57(4):918-28
• All: 1 reference(s)