Nr1i2^{tm1(NR1I2)Arte}
Targeted Allele Detail

Summary

• Symbol: Nr1i2^{tm1(NR1I2)Arte}
• Name: nuclear receptor subfamily 1, group I, member 2; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:3790844
• Synonyms: huPXR
• Gene: Nr1i2 Location: Chr16:38068711-38115211 bp, - strand Genetic Position: Chr16, 26.64 cM
• Alliance: Nr1i2^{tm1(NR1I2)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140975
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Nr1i2^{tm1(NR1I2)Arte} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NR1I2 (8856)

  Nr1i2

  (MGI:1337040)

• Mutation details: Exon 2 was replaced with a human cDNA encoding exons 2-4, intron 4, exon 5, intron 5, and fusion of exons 6-9 with an frt-flanked hygro cassette. The sequence was flanked by an attB53 site at the 5' end and an attP50 site at the 3' end. Germ line, flp mediated recombination was used to remove the hygro cassette. The absence of the endogenous transcript expression was confirmed by qPCR on liver and small intestine extracts. (J:140975)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nr1i2 Mutation: 35 strains or lines available

References

• Original: J:140975 Scheer N, et al., A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J Clin Invest. 2008 Sep;118(9):3228-39
• All: 12 reference(s)