Mirc2^tm1.1Tyj
Targeted Allele Detail

Summary

• Symbol: Mirc2^tm1.1Tyj
• Name: microRNA cluster 2, including Mir363 through Mir106a; targeted mutation 1.1, Tyler Jacks
• MGI ID: MGI:3790966
• Synonyms: miR-106a~393^delta
• Gene: Mirc2 Location: ChrX:51830570-51831444 bp Genetic Position: ChrX, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134861
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: The Mir106a, Mir18b, Mir20b, Mir19b-2, Mir92-2, and Mir363 genes were replaced by an Frt-flanked neomycin cassette. The targeting vector was introduced to V6.5 (C57BL/6 x 129S4/SvJae)F1-derived embryonic stem (ES) cells. The neomycin cassette was removed through Flp-mediated excision. (J:134861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc2 Mutation: 1 strain or line available

References

• Original: J:134861 Ventura A, et al., Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008 Mar 7;132(5):875-86
• All: 9 reference(s)