Mirc1^tm1.2Tyj
Targeted Allele Detail

Summary

• Symbol: Mirc1^tm1.2Tyj
• Name: microRNA cluster 1, including Mir17 through Mir92-1; targeted mutation 1.2, Tyler Jacks
• MGI ID: MGI:3790968
• Synonyms: miR-17~92^delta, Mirn17-92^tm1.2Tyj
• Gene: Mirc1 Location: Chr14:115281103-115281938 bp Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134861
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: Crossing Mirc1^tm1.1Tyj mice to a Cre deleter strain (human ACTB beta actin promoter) excised the floxed cluster, including Mir17, Mir18a, Mir19a, Mir20a, Mir19b-1, and Mir92-1. This results in a null allele. (J:134861)

Disease models

Expression

In Mice Carrying this Mutation:	208072 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc1 Mutation: 6 strains or lines available

References

• Original: J:134861 Ventura A, et al., Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008 Mar 7;132(5):875-86
• All: 12 reference(s)