Ror2^tm1Anec
Targeted Allele Detail

Summary

• Symbol: Ror2^tm1Anec
• Name: receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1, Aris N Economides
• MGI ID: MGI:3793279
• Synonyms: Ror2^W749FLAG, Ror2^W749X
• Gene: Ror2 Location: Chr13:53263353-53440160 bp, - strand Genetic Position: Chr13, 27.68 cM, cytoband B3
• Alliance: Ror2^tm1Anec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134490
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region encoding W749 to D930 was replaced with a fused, in-frame FLAG-encoding sequence followed by a neo cassette. RT-PCR confirmed the absence of wild-type transcript and the presence of the tagged truncated product in E15.5 embryos. (J:134490)

Disease models

Expression

In Structures Affected by this Mutation:

21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ror2 Mutation: 125 strains or lines available

References

• Original: J:134490 Raz R, et al., The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Development. 2008 May;135(9):1713-23
• All: 4 reference(s)