Wnt7b^tm2.1Amc
Targeted Allele Detail

Summary

• Symbol: Wnt7b^tm2.1Amc
• Name: wingless-type MMTV integration site family, member 7B; targeted mutation 2.1, Andrew P McMahon
• MGI ID: MGI:3793280
• Synonyms: Wnt7b^D3, Wnt7b^delta
• Gene: Wnt7b Location: Chr15:85419638-85466022 bp, - strand Genetic Position: Chr15, 40.39 cM
• Alliance: Wnt7b^tm2.1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134483
• Parent Cell Line: AV3 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove exon 3. The absence of transcript from this allele was confirmed by RT-PCR and in situ hybridization following recombination in embryos. (J:134483)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt7b Mutation: 17 strains or lines available

References

• Original: J:134483 Rajagopal J, et al., Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development. 2008 May;135(9):1625-34
• All: 4 reference(s)