Egln1^tm1.1Kael
Targeted Allele Detail

Summary

• Symbol: Egln1^tm1.1Kael
• Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 1.1, William G Kaelin
• MGI ID: MGI:3793288
• Synonyms: PHD2^-
• Gene: Egln1 Location: Chr8:125635326-125676063 bp, - strand Genetic Position: Chr8, 72.86 cM
• Alliance: Egln1^tm1.1Kael page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132718
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed exon 2 and 3 of Egln1^tm1Kael were removed via cre-mediated recombination by mating with Tg(EIIa-cre)C5379Lmgd mice. Egln1 mRNA and protein are undetectable in MEFs isolated from E12.5 embryos. (J:132718)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egln1 Mutation: 22 strains or lines available

References

• Original: J:132718 Minamishima YA, et al., Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood. 2008 Mar 15;111(6):3236-44
• All: 3 reference(s)