Bub1^tm1.1Jvd
Targeted Allele Detail

Summary

• Symbol: Bub1^tm1.1Jvd
• Name: BUB1, mitotic checkpoint serine/threonine kinase; targeted mutation 1.1, Jan M A van Deursen
• MGI ID: MGI:3793293
• Synonyms: Bub1^-
• Gene: Bub1 Location: Chr2:127643036-127673785 bp, - strand Genetic Position: Chr2, 62.1 cM
• Alliance: Bub1^tm1.1Jvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135093
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediate recombnation was used to remove exon 9. The absence of protein product was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:135093)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bub1^tm1.1Jvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub1 Mutation: 52 strains or lines available

References

• Original: J:135093 Jeganathan K, et al., Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol. 2007 Oct 22;179(2):255-67
• All: 2 reference(s)