Bub1^tm2Jvd
Targeted Allele Detail

Summary

• Symbol: Bub1^tm2Jvd
• Name: BUB1, mitotic checkpoint serine/threonine kinase; targeted mutation 2, Jan M A van Deursen
• MGI ID: MGI:3793294
• Synonyms: Bub1^H
• Gene: Bub1 Location: Chr2:127643036-127673785 bp, - strand Genetic Position: Chr2, 62.1 cM
• Alliance: Bub1^tm2Jvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135093
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A hygro cassette was inserted into intron 9. This is a hypomorphic allele expressing at 20% of wild-type as determined by quantitative western blot analysis on mouse embryonic fibroblasts. (J:135093)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bub1^tm2Jvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub1 Mutation: 52 strains or lines available

References

• Original: J:135093 Jeganathan K, et al., Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol. 2007 Oct 22;179(2):255-67
• All: 3 reference(s)