Gp1bb^tm2Frla
Targeted Allele Detail

Summary

• Symbol: Gp1bb^tm2Frla
• Name: glycoprotein Ib, beta polypeptide; targeted mutation 2, Francois Lanza
• MGI ID: MGI:3793297
• Synonyms: GPIbbetadeltaIC
• Gene: Gp1bb Location: Chr16:18439069-18441153 bp, - strand Genetic Position: Chr16, 11.53 cM
• Alliance: Gp1bb^tm2Frla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135065
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Humanized sequence, Hypomorph, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted upstream of the coding region and the coding region was replaced with one in which the intracellular domain has been deleted. Cre mediated recombination was used to remove the neo cassette. (J:135065)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gp1bb Mutation: 2 strains or lines available

References

• Original: J:135065 Strassel C, et al., Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome. Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):241-7
• All: 1 reference(s)