Gad1^tm2Oba
Targeted Allele Detail

Summary

• Symbol: Gad1^tm2Oba
• Name: glutamate decarboxylase 1; targeted mutation 2, Kunihiko Obata
• MGI ID: MGI:3793303
• Synonyms: GAD67^flox
• Gene: Gad1 Location: Chr2:70392109-70432358 bp, + strand Genetic Position: Chr2, 41.63 cM, cytoband D
• Alliance: Gad1^tm2Oba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134497
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 1 floxed. (J:134497)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gad1 Mutation: 65 strains or lines available

References

• Original: J:134497 Obata K, et al., GABA and synaptic inhibition of mouse cerebellum lacking glutamate decarboxylase 67. Biochem Biophys Res Commun. 2008 Jun 6;370(3):429-33
• All: 6 reference(s)