Mapt^tm2(cre)Aha
Targeted Allele Detail

Summary

• Symbol: Mapt^tm2(cre)Aha
• Name: microtubule-associated protein tau; targeted mutation 2, Akihiro Harada
• MGI ID: MGI:3793311
• Synonyms: tau-Cre
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm2(cre)Aha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134499
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Mapt^tm2(cre)Aha expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mapt (MGI:97180)

• Mutation details: A cre gene with a nuclear localization signal followed by an frt-flanked neo cassette was inserted immediately after the start methionine. Cre function is dectected in neurons of almost all areas of the brain with only granule cells in the caudal part of the cerebellum not exhbiting cre function. Other organs such as the liver, kidney and intestine do not exhibit cre function. (J:134499)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mapt (mouse) Summary of all recombinase alleles driven by Mapt. Comparative matrix view of recombinase activities Alliance mouse Mapt gene page

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:134499 Muramatsu K, et al., Neuron-specific recombination by Cre recombinase inserted into the murine tau locus. Biochem Biophys Res Commun. 2008 Jun 6;370(3):419-23
• All: 7 reference(s)