Nat1^Rgsc1523
Chemically induced Allele Detail

Summary

• Symbol: Nat1^Rgsc1523
• Name: N-acetyl transferase 1; RIKEN Genomic Sciences Center (GSC), 1523
• MGI ID: MGI:3793317
• Synonyms: Nat1^I95T
• Gene: Nat1 Location: Chr8:67943620-67945183 bp, + strand Genetic Position: Chr8, 33.38 cM, cytoband B3.1
• Alliance: Nat1^Rgsc1523 page

Mutation origin

• Strain of Origin: C57BL/6
• Project Collection: RIKEN GSC ENU Project

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis generated a C to T transition that results in an amino acid substitution of threonine for isoleucine at position 95 (I95T). This mutation results in a 90% decrease in enzymatic activity. (J:134504)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nat1 Mutation: 19 strains or lines available

References

• Original: J:134504 Erickson RP, et al., An N-ethyl-N-nitrosourea-induced mutation in N-acetyltransferase 1 in mice. Biochem Biophys Res Commun. 2008 May 30;370(2):285-8
• All: 1 reference(s)