Gria1^tm5Rlh
Targeted Allele Detail

Summary

• Symbol: Gria1^tm5Rlh
• Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 5, Richard L Huganir
• MGI ID: MGI:3793349
• Synonyms: Gria1^{Ser 831}
• Gene: Gria1 Location: Chr11:56902342-57221070 bp, + strand Genetic Position: Chr11, 34.51 cM
• Alliance: Gria1^tm5Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135196
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: Exon 17 was replaced with one in which a nucleotide substitution resulted in an amio acid substitution of alanine for serine at position 831 (S831A). A neo cassette used as a selectable marker was removed by germline, cre-mediated recombination. (J:135196)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria1 Mutation: 65 strains or lines available

References

• Original: J:135196 Crombag HS, et al., A necessary role for GluR1 serine 831 phosphorylation in appetitive incentive learning. Behav Brain Res. 2008 Aug 22;191(2):178-83
• All: 7 reference(s)