Rock2^tm1.1Liao
Targeted Allele Detail

Summary

• Symbol: Rock2^tm1.1Liao
• Name: Rho-associated coiled-coil containing protein kinase 2; targeted mutation 1.1, James K Liao
• MGI ID: MGI:3793462
• Gene: Rock2 Location: Chr12:16944896-17037824 bp, + strand Genetic Position: Chr12, 8.04 cM, cytoband A3
• Alliance: Rock2^tm1.1Liao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135152
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette with a 3' loxP site was inserted downstream of exon 3 and an additional loxP site was inserted upstream of exon 3. Cre-mediated recombination in ES cells was used to remove the neo cassette and exon 3. The absence of protein product from the allele was confirmed by a 50% reduction in protein in heterozygotes as determined by western blot analysis on heart and kidney extracts. (J:135152)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rock2 Mutation: 60 strains or lines available

References

• Original: J:135152 Noma K, et al., ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury. J Clin Invest. 2008 May;118(5):1632-44
• All: 10 reference(s)