Tg(Myh6-TNNT2*I79N)9Jdp
Transgene Detail
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Symbol: |
Tg(Myh6-TNNT2*I79N)9Jdp |
Name: |
transgene insertion 9, James D Potter |
MGI ID: |
MGI:3793478 |
Synonyms: |
HCTnT-I79N, Tg-I79N |
Transgene: |
Tg(Myh6-TNNT2*I79N)9Jdp Location: unknown
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Alliance: |
Tg(Myh6-TNNT2*I79N)9Jdp page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Myh6-TNNT2*I79N)9Jdp expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
TNNT2 (7139) |
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Transgene codes for a protein with an isoleucine to asparagine mutation. |
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Mutation details: The transgene construct consists of about 5.5 kilobases of the mouse alpha-myosin
heavy chain promoter, including the first 2 exons and part of the third,
followed by the human TNNT2 cDNA (876 base pairs) modified to express a I79N mutation, and a 630-base pair 3'-untranslated region from the human growth hormone transcript.
(J:67284)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:67284 Miller T, et al., Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation. J Biol Chem. 2001 Feb 9;276(6):3743-55 |
All: |
4 reference(s) |
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