Tg(H2-Aa)26Dim
Transgene Detail

Summary

• Symbol: Tg(H2-Aa)26Dim
• Name: transgene insertion 26, Diane Mathis
• MGI ID: MGI:3793688
• Synonyms: Aa26
• Transgene: Tg(H2-Aa)26Dim Location: unknown
• Alliance: Tg(H2-Aa)26Dim page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-Aa)26Dim expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-Aa (MGI:95895)

• Mutation details: A transgenic construct containing the entire mouse (AKR/J strain) H2-Aa kappa genomic DNA sequence was microinjected into (C57BL/6 x SJL)F2 embryos. Two lines A_alpha10 and A_alpha26 were generated. Line 26 was crossed to mice carrying Tg(H2-Ab1)62Dim and the resulting double transgenic line was donated to The Jackson Laboratory. The construct was also injected into C57BL/6 embryos to have the transgene on a homogeneous genetic background. Line 46 was established (A_alpha46). S1-mapping shows normal patterns of high expression in spleen, lung and thymus. (J:110897)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:110897 Fehling HJ, et al., Functional consequences of overexpressed Ia antigens in AK alpha/AK beta transgenic mice. J Immunol. 1990 Apr 15;144(8):2865-74
• All: 2 reference(s)