Ndufs4^tm1.1Rpa
Targeted Allele Detail

Summary

• Symbol: Ndufs4^tm1.1Rpa
• Name: NADH:ubiquinone oxidoreductase core subunit S4; targeted mutation 1.1, Richard D Palmiter
• MGI ID: MGI:3793713
• Synonyms: Ndufs4^delta, Ndufs4 KO
• Gene: Ndufs4 Location: Chr13:114424331-114524630 bp, - strand Genetic Position: Chr13, 64.12 cM, cytoband D2.2
• Alliance: Ndufs4^tm1.1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134334
• Parent Cell Line: AK18.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exon 2, which contains the mitochondrial targeting sequence. The absence of protein product was confirmed by western blot analysis. (J:134334)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ndufs4 Mutation: 29 strains or lines available

References

• Original: J:134334 Kruse SE, et al., Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. Cell Metab. 2008 Apr;7(4):312-20
• All: 56 reference(s)