Tg(Myh6*)140Lnwd
Transgene Detail

Summary

• Symbol: Tg(Myh6*)140Lnwd
• Name: transgene insertion 140, Leslie Leinwand
• MGI ID: MGI:3793715
• Synonyms: HCM
• Transgene: Tg(Myh6*)140Lnwd Location: unknown
• Alliance: Tg(Myh6*)140Lnwd page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6*)140Lnwd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Myh6 (29556)

  Myh6	(MGI:97255)

• Tg(Myh6*)140Lnwd expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Myh6 (29556)

  Myh6	(MGI:97255)

• Mutation details: A rat myosin heavy chain promoter drives the expression of a rat cardiac alpha myosin heavy chain (Myh6) cDNA that was modified by mutating residue 1445 from a G to an A, and the deletion of codons 468-527. This resulted in a R403G substitution and a deletion in the putative actin binding domain in the encoded protein. This transgenic line exhibits a strong phenotype. (J:36522)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:36522 Vikstrom KL, et al., Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy. Mol Med. 1996 Sep;2(5):556-67
• All: 25 reference(s)