Foxp2^R552H
Chemically induced Allele Detail

Summary

• Symbol: Foxp2^R552H
• Name: forkhead box P2; Arg552His
• MGI ID: MGI:3793742
• Synonyms: Foxp2-R552H
• Gene: Foxp2 Location: Chr6:14901348-15441976 bp, + strand Genetic Position: Chr6, 6.49 cM, cytoband A2
• Alliance: Foxp2^R552H page

Mutation origin

• Strain of Origin: (C3H/HeH x BALB/c)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis generated a nucleotide substitution that resulted in an amino acid substitution of histidine for arginine at position 552 (R552H). This mutation is predicted to disrupt the DNA binding and transactivation properties of the protein. (J:135404)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp2 Mutation: 52 strains or lines available

References

• Original: J:93069 Quwailid MM, et al., A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm Genome. 2004 Aug;15(8):585-91
• All: 10 reference(s)