Foxp2^N549K
Chemically induced Allele Detail

Summary

• Symbol: Foxp2^N549K
• Name: forkhead box P2; Asp549Lys
• MGI ID: MGI:3793745
• Synonyms: Foxp2-N549K
• Gene: Foxp2 Location: Chr6:14901348-15441976 bp, + strand Genetic Position: Chr6, 6.49 cM, cytoband A2
• Alliance: Foxp2^N549K page

Mutation origin

• Strain of Origin: (C3H/HeH x BALB/c)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis generated a nucleotide substitution that resulted in an amino acid substitution of lysine for asparagine at position 549 (N549K). This mutation is predicted to disrupt the DNA binding domain. (J:135404)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp2 Mutation: 52 strains or lines available

References

• Original: J:93069 Quwailid MM, et al., A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm Genome. 2004 Aug;15(8):585-91
• All: 2 reference(s)