Foxp2^S321X
Chemically induced Allele Detail

Summary

• Symbol: Foxp2^S321X
• Name: forkhead box P2; Ser321Stop
• MGI ID: MGI:3793751
• Synonyms: Foxp2-S321X
• Gene: Foxp2 Location: Chr6:14901348-15441976 bp, + strand Genetic Position: Chr6, 6.49 cM, cytoband A2
• Alliance: Foxp2^S321X page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis generated a nucleotide substitution that resulted in an amino acid substitution of a STOP codon for serine at position 321 (S321X). This mutation is predicted to cause a premature truncation of the protein similar to one found in human patients with FOXP2-related speech and language difficulties (R328X). (J:135404)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp2 Mutation: 52 strains or lines available

References

• Original: J:100122 Augustin M, et al., Efficient and fast targeted production of murine models based on ENU mutagenesis. Mamm Genome. 2005 Jun;16(6):405-13
• All: 8 reference(s)