Plxna2^tm1Hfu
Targeted Allele Detail

Summary

• Symbol: Plxna2^tm1Hfu
• Name: plexin A2; targeted mutation 1, Hajime Fujisawa
• MGI ID: MGI:3793763
• Gene: Plxna2 Location: Chr1:194302020-194499177 bp, + strand Genetic Position: Chr1, 98.27 cM, cytoband H6
• Alliance: Plxna2^tm1Hfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135421
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP-IRES Tak PGK-Neo cassette was inserted into the open reading frame downstream of the signal sequence. The absence of protein product was confirmed by western blot analysis on brain extracts. (J:135421)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plxna2 Mutation: 130 strains or lines available

References

• Original: J:135421 Suto F, et al., Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers. Neuron. 2007 Feb 15;53(4):535-47
• All: 21 reference(s)