Plxna2^nmf454
Chemically induced Allele Detail

Summary

• Symbol: Plxna2^nmf454
• Name: plexin A2; neuroscience mutagenesis facility 454
• MGI ID: MGI:3793765
• Synonyms: NMF454
• Gene: Plxna2 Location: Chr1:194302020-194499177 bp, + strand Genetic Position: Chr1, 98.27 cM, cytoband H6
• Alliance: Plxna2^nmf454 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis was used to induce a nucleotide substitution that resulted in an amino acid substitution of glutamic acid for alanine at position 396 (A396E). This amino acid is involved in Sema6a binding to plexin-A2. (J:135408)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plxna2 Mutation: 130 strains or lines available

References

• Original: J:135408 Renaud J, et al., Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells. Nat Neurosci. 2008 Apr;11(4):440-9
• All: 1 reference(s)