Gt(ROSA)26Sor^{tm1(RARA*)Soc}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(RARA*)Soc}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Shanthini Sockanathan
• MGI ID: MGI:3793772
• Synonyms: dnRAR-alpha, R26^RAR403, Rara403 conditional
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(RARA*)Soc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Dominant negative, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(RARA*)Soc} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RARA (5914)

  Rara	(MGI:97856)

• Mutation details: A floxed neo-STOP cassette followed by a dominant negative form of human RARA (RAR403) was inserted into the ROSA locus. Cre mediated removal of the neo-STOP cassette is necessary for expression of RAR403. (J:135403)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:135403 Rajaii F, et al., Expression of the dominant negative retinoid receptor, RAR403, alters telencephalic progenitor proliferation, survival, and cell fate specification. Dev Biol. 2008 Apr 15;316(2):371-82
• All: 18 reference(s)