Hs6st1^tm1.1Wvc
Targeted Allele Detail

Summary

• Symbol: Hs6st1^tm1.1Wvc
• Name: heparan sulfate 6-O-sulfotransferase 1; targeted mutation 1.1, Wellington V Cardoso
• MGI ID: MGI:3793787
• Synonyms: Hs6st1^-
• Gene: Hs6st1 Location: Chr1:36107481-36145527 bp, + strand Genetic Position: Chr1, 15.15 cM, cytoband B
• Alliance: Hs6st1^tm1.1Wvc page

Decrease in weight and survival of Hs6st1^tm1.1Wvc/Hs6st1^tm1.1Wvc mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135241
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exon 1, which contains the start methionine codon and encodes the PAPs binding domain. RT-PCR confirmed weak expression of the truncated transcript that encodes a protein expected to have little enzymatic activity. (J:135241)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hs6st1 Mutation: 27 strains or lines available

References

• Original: J:135241 Izvolsky KI, et al., Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis. 2008 Jan;46(1):8-18
• All: 1 reference(s)