Neu4^tm1Avps
Targeted Allele Detail

Summary

• Symbol: Neu4^tm1Avps
• Name: sialidase 4; targeted mutation 1, Alexey V Pschezhetsky
• MGI ID: MGI:3793789
• Gene: Neu4 Location: Chr1:93948215-93956056 bp, + strand Genetic Position: Chr1, 47.46 cM
• Alliance: Neu4^tm1Avps page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135246
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 was replaced with a neo cassette. The absence of full-length transcript as confirmed by northern blot and RT-PCR analysis on brain extracts. (J:135246)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neu4 Mutation: 23 strains or lines available

References

• Original: J:135246 Seyrantepe V, et al., Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage. Hum Mol Genet. 2008 Jun 1;17(11):1556-68
• All: 5 reference(s)