Pkd1^tm2Som
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm2Som
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 2, Stefan Somlo
• MGI ID: MGI:3793791
• Synonyms: Pkd1^flox
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm2Som page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135301
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 4 and an additional loxP was inserted upstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette and leave exons 2 to 4 floxed. (J:135301)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 154 strains or lines available

References

• Original: J:135301 Shibazaki S, et al., Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet. 2008 Jun 1;17(11):1505-16
• All: 42 reference(s)