Pkd1^tm2.1Som
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm2.1Som
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 2.1, Stefan Somlo
• MGI ID: MGI:3793792
• Synonyms: Pkd1^del2-4
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm2.1Som page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135301
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Germ line, cre-mediated recombination was used to remove exons 2 through 4. (J:135301)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 154 strains or lines available

References

• Original: J:135301 Shibazaki S, et al., Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet. 2008 Jun 1;17(11):1505-16
• All: 3 reference(s)