Tg(Myl1-Igf1)1Nros
Transgene Detail

Summary

• Symbol: Tg(Myl1-Igf1)1Nros
• Name: transgene insertion 1, Nadia Rosenthal
• MGI ID: MGI:3793794
• Synonyms: mIGF-1, MLC/mIgf-1
• Transgene: Tg(Myl1-Igf1)1Nros Location: unknown
• Alliance: Tg(Myl1-Igf1)1Nros page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myl1-Igf1)1Nros expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Igf1 (24482)

  Igf1	(MGI:96432)

• Mutation details: The transgene construct consists of a rat mIgf-1 cDNA driven by skeletal muscle-specific regulatory elements from the rat myosin light chain (MLC)-1/3 locus. Expression of the MLC/mIgf-1 transgene in adult mice was restricted to skeletal muscle and predominated in muscles enriched in fast fibers, such as the triceps or gastrocnemius. Transgene expression was reduced in slow muscles such as the soleus, where the MLC regulatory cassette is characteristically expressed at very low levels. (J:96432)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:96432 Musaro A, et al., Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nat Genet. 2001 Feb;27(2):195-200
• All: 20 reference(s)