Tg(Pdgfb-icre/ERT2,-EGFP)1Frut
Transgene Detail

Summary

• Symbol: Tg(Pdgfb-icre/ERT2,-EGFP)1Frut
• Name: transgene insertion 1, Marcus Fruttiger
• MGI ID: MGI:3793852
• Synonyms: Pdgfb-iCreER, Pdgfb-iCre-ERT2-Egfp, Tg(Pdgfb-cre/ERT2)1Frut, Tg(Pdgfb-cre/ESR1)1Frut
• Transgene: Tg(Pdgfb-icre/ERT2,-EGFP)1Frut Location: unknown
• Alliance: Tg(Pdgfb-icre/ERT2,-EGFP)1Frut page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Pdgfb-icre/ERT2,-EGFP)1Frut expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pdgfb (MGI:97528)

• Mutation details: The mouse Pdgfb promoter was used to drive inducible expression of an improved cre gene fused to ERT2 and followed by an IRES-EGFP then an frt-flanked chloramphenicol resistance gene in vascular endothelium. The PAC used (RP21-629-J8) contains the entire Pdgfb gene with the cre cassette inserted immediately following the start methionine codon. No line information was given. (J:135315)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdgfb (mouse) Summary of all recombinase alleles driven by Pdgfb. Comparative matrix view of recombinase activities Alliance mouse Pdgfb gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:135315 Claxton S, et al., Efficient, inducible Cre-recombinase activation in vascular endothelium. Genesis. 2008 Feb;46(2):74-80
• All: 155 reference(s)