Tbc1d4^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Tbc1d4^tm1Lex
• Name: TBC1 domain family, member 4; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3793866
• Gene: Tbc1d4 Location: Chr14:101679796-101846627 bp, - strand Genetic Position: Chr14, 50.9 cM
• Alliance: Tbc1d4^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135310
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the brown adipose tissue, white adipose tissue and soleus. (J:191749)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbc1d4 Mutation: 51 strains or lines available

References

• Original: J:135310 Chavez JA, et al., Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem. 2008 Apr 4;283(14):9187-95
• All: 12 reference(s)