Atxn2^tm1.1Aub
Targeted Allele Detail

Summary

• Symbol: Atxn2^tm1.1Aub
• Name: ataxin 2; targeted mutation 1.1, Georg Auburger
• MGI ID: MGI:3793867
• Synonyms: Atxn2^tm1.1Geno, Sca2^-
• Gene: Atxn2 Location: Chr5:121849794-121954372 bp, + strand Genetic Position: Chr5, 61.93 cM, cytoband F
• Alliance: Atxn2^tm1.1Aub page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135320
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. Transient cre expression in ES cells ws used to remove exon 1 and the neo cassette. The absence of protein product was confirmed by western blot analysis on brain extracts. (J:135320)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atxn2 Mutation: 90 strains or lines available

References

• Original: J:135320 Lastres-Becker I, et al., Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice. Hum Mol Genet. 2008 May 15;17(10):1465-81
• All: 8 reference(s)