Tg(MMTV-Erbb2*)NDL2-5Mul
Transgene Detail

Summary

• Symbol: Tg(MMTV-Erbb2*)NDL2-5Mul
• Name: transgene insertion NDL2-5, William J Muller
• MGI ID: MGI:3793949
• Synonyms: MMTV-NDL, MMTV-Neu2-5, MMTV-neuNDL2-5, NDL2-5
• Transgene: Tg(MMTV-Erbb2*)NDL2-5Mul Location: unknown
• Alliance: Tg(MMTV-Erbb2*)NDL2-5Mul page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Erbb2*)NDL2-5Mul expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

• Mutation details: A rat Erbb2 cDNA containing an activating mutation is expressed under the control of the MMTV LTR with SV40 polyadenylation and splicing signals. The activating mutation, derived from a clone isolated from mouse mammary tumor tissue, consists of a 5 codon in-frame deletion (neu8342) in the region encoding the extracellular region directly adjacent to the transmembrane domain. The major sites of expression of the transgene in female carriers include the mammary and salivary glands with lower levels detectable in lungs and ovaries. In male carriers, transgene expression is detectable in salivary gland and reproductive organs, with variable expression in mammary gland and lungs. (J:54661)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-Erbb2*)NDL2-5Mul

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:54661 Siegel PM, et al., Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer. EMBO J. 1999 Apr 15;18(8):2149-64
• All: 21 reference(s)