Wnt7b^tm1.1Amc
Targeted Allele Detail

Summary

• Symbol: Wnt7b^tm1.1Amc
• Name: wingless-type MMTV integration site family, member 7B; targeted mutation 1.1, Andrew P McMahon
• MGI ID: MGI:3793960
• Synonyms: Wnt7b^D1
• Gene: Wnt7b Location: Chr15:85419638-85466022 bp, - strand Genetic Position: Chr15, 40.39 cM
• Alliance: Wnt7b^tm1.1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101493
• Parent Cell Line: AV3 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove exon 1. This is a hypomorphic allele that expresses at 10% of wild-type due to a cryptic upstream exon is spliced into the transcript. (J:101493)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt7b Mutation: 17 strains or lines available

References

• Original: J:101493 Lobov IB, et al., WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature. 2005 Sep 15;437(7057):417-21
• All: 3 reference(s)