Cdc73^tm1Btt
Targeted Allele Detail

Summary

• Symbol: Cdc73^tm1Btt
• Name: cell division cycle 73, Paf1/RNA polymerase II complex component; targeted mutation 1, Bin Tean Teh
• MGI ID: MGI:3794030
• Synonyms: Hrpt2^L
• Gene: Cdc73 Location: Chr1:143479014-143578631 bp, - strand Genetic Position: Chr1, 62.52 cM
• Alliance: Cdc73^tm1Btt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135255
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2 and an additional loxP site was inserted upstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed. (J:135255)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdc73^tm1Btt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc73 Mutation: 45 strains or lines available

References

• Original: J:135255 Wang P, et al., Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol. 2008 May;28(9):2930-40
• All: 5 reference(s)