Abcc5^tm1Bor
Targeted Allele Detail

Summary

• Symbol: Abcc5^tm1Bor
• Name: ATP-binding cassette, sub-family C member 5; targeted mutation 1, Piet Borst
• MGI ID: MGI:3794119
• Gene: Abcc5 Location: Chr16:20150053-20245144 bp, - strand Genetic Position: Chr16, 12.41 cM
• Alliance: Abcc5^tm1Bor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135561
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.5 kb segment of genomic DNA containing exon 17 that encodes amino acids 678 to 745 of the first ATP-binding domain was replaced with a hygro cassette. The absence of protein product was confirmed by western blot analysis on erythrocye vesicle extracts. (J:135561)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc5 Mutation: 143 strains or lines available

References

• Original: J:135561 de Wolf CJ, et al., cGMP transport by vesicles from human and mouse erythrocytes. FEBS J. 2007 Jan;274(2):439-50
• All: 4 reference(s)