Mtbp^tm1Glo
Targeted Allele Detail

Summary

• Symbol: Mtbp^tm1Glo
• Name: Mdm2, transformed 3T3 cell double minute p53 binding protein; targeted mutation 1, Guillermina Lozano
• MGI ID: MGI:3794647
• Gene: Mtbp Location: Chr15:55420804-55489819 bp, + strand Genetic Position: Chr15, 22.05 cM
• Alliance: Mtbp^tm1Glo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135509
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene followed by a neo cassette was inserted immediately downstream of the initiation methionine in exon 1. The absence of protein product from this allele was confirmed by western blot analysis on heterozygous thymocytes. This is a null allele and a reporter allele. (J:135509)

Tumor Data

List all tumor models in MMHCdb carrying Mtbp^tm1Glo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtbp Mutation: 56 strains or lines available

References

• Original: J:135509 Iwakuma T, et al., Mtbp haploinsufficiency in mice increases tumor metastasis. Oncogene. 2008 Mar 20;27(13):1813-20
• All: 2 reference(s)