Wt1^tm1Mlh
Targeted Allele Detail

Summary

• Symbol: Wt1^tm1Mlh
• Name: WT1 transcription factor; targeted mutation 1, Martin L Hooper
• MGI ID: MGI:3794650
• Synonyms: Wt1^tmT396
• Gene: Wt1 Location: Chr2:104956874-105003959 bp, + strand Genetic Position: Chr2, 55.06 cM, cytoband E
• Alliance: Wt1^tm1Mlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135449
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 9 was replaced with one that contains an inserted Leu2/neo cassette that causes an amino acid substitution of arginine for serine at position 395 (S395R) and premature termination within the zinc finger 3 domain by inclusion of a translation stop codon at position 396. (J:135449)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Wt1 Mutation: 34 strains or lines available

References

• Original: J:135449 Patek CE, et al., Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1 (tmT396)). Transgenic Res. 2008 Jun;17(3):459-75
• All: 1 reference(s)