Shox2^tm1Acgg
Targeted Allele Detail

Summary

• Symbol: Shox2^tm1Acgg
• Name: SHOX homeobox 2; targeted mutation 1, Adrianna C Gittenberger-De Groot
• MGI ID: MGI:3794658
• Gene: Shox2 Location: Chr3:66879060-66889104 bp, - strand Genetic Position: Chr3, 30.76 cM, cytoband E3-F1
• Alliance: Shox2^tm1Acgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135454
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neo cassette. The absence of both a and b transcripts were confirmed by RT-PCR on E10.5 heart extracts. (J:135454)

Expression

In Mice Carrying this Mutation:	79 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shox2 Mutation: 20 strains or lines available

Notes

ES cell line = RI ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺) or E14 (129P2/OlaHsd).

References

• Original: J:135454 Blaschke RJ, et al., Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development. Circulation. 2007 Apr 10;115(14):1830-8
• All: 6 reference(s)