Ppp4ctm1Htn
Targeted Allele Detail
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Symbol: |
Ppp4ctm1Htn |
Name: |
protein phosphatase 4, catalytic subunit; targeted mutation 1, Shinji Hirotsune |
MGI ID: |
MGI:3794733 |
Synonyms: |
PP4cneo, Tbx6/Ppp4ctm1Htn |
Gene: |
Ppp4c Location: Chr7:126385038-126391668 bp, - strand Genetic Position: Chr7, 69.25 cM
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Alliance: |
Ppp4ctm1Htn page
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Germline Transmission: |
Earliest citation of germline transmission:
J:134682
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Ppp4ctm1Htn involves 1 genes/genome features (Tbx6)
View all
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Mutation details: A loxP site was inserted in between exons 4 and 5. A floxed neomycin resistance cassette was inserted downstream of exon 8 and also replaced the codons of the last 4 amino acids of Tbx6. Northern blot analysis confirmed reduced Ppp4c transcript expression in embryo. RT-PCR confirmed normal Tbx6 transcript expression.
(J:134682)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ppp4c Mutation: |
41 strains or lines available
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Original: |
J:134682 Toyo-oka K, et al., Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation. J Cell Biol. 2008 Mar 24;180(6):1133-47 |
All: |
1 reference(s) |
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