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Ppp4ctm1Htn
Targeted Allele Detail
Summary
Symbol: Ppp4ctm1Htn
Name: protein phosphatase 4, catalytic subunit; targeted mutation 1, Shinji Hirotsune
MGI ID: MGI:3794733
Synonyms: PP4cneo, Tbx6/Ppp4ctm1Htn
Gene: Ppp4c  Location: Chr7:126385038-126391668 bp, - strand  Genetic Position: Chr7, 69.25 cM
Alliance: Ppp4ctm1Htn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134682
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
  Ppp4ctm1Htn involves 1 genes/genome features (Tbx6) View all
 
Mutation detailsA loxP site was inserted in between exons 4 and 5. A floxed neomycin resistance cassette was inserted downstream of exon 8 and also replaced the codons of the last 4 amino acids of Tbx6. Northern blot analysis confirmed reduced Ppp4c transcript expression in embryo. RT-PCR confirmed normal Tbx6 transcript expression. (J:134682)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp4c Mutation:  41 strains or lines available
References
Original:  J:134682 Toyo-oka K, et al., Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation. J Cell Biol. 2008 Mar 24;180(6):1133-47
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory