Ccn3^tm1Cabo
Targeted Allele Detail

Summary

• Symbol: Ccn3^tm1Cabo
• Name: cellular communication network factor 3; targeted mutation 1, Catherine A Boulter
• MGI ID: MGI:3794783
• Synonyms: Nov^del3
• Gene: Ccn3 Location: Chr15:54609306-54617158 bp, + strand Genetic Position: Chr15, 21.49 cM
• Alliance: Ccn3^tm1Cabo page

Abnormal skeletal development in Ccn3^tm1Cabo/Ccn3^tm1Cabo and Ccn3^tm1Cabo/Nov⁺ mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135676
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neo cassette. The absence of full-length protein product was confirmed by western blot analysis on whole cell extracts from E13.5 primary embryonic fibroblasts. A truncated protein product is observed at low levels in western blots of conditioned media from E13.5 primary embryonic fibroblasts but lacks the VWC domain. (J:135676)

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccn3 Mutation: 22 strains or lines available

References

• Original: J:135676 Heath E, et al., Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene. BMC Dev Biol. 2008;8:18
• All: 1 reference(s)