Ppp1r13b^tm1Suda
Targeted Allele Detail

Summary

• Symbol: Ppp1r13b^tm1Suda
• Name: protein phosphatase 1, regulatory subunit 13B; targeted mutation 1, Toshio Suda
• MGI ID: MGI:3794784
• Synonyms: Aspp1^-
• Gene: Ppp1r13b Location: Chr12:111794891-111874544 bp, - strand Genetic Position: Chr12, 61.14 cM, cytoband F2
• Alliance: Ppp1r13b^tm1Suda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135686
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 and exon 3 were replaced with an IRES-lacZ and floxed neo cassette. Germ line, cre-mediated recombination was used to remove the neo cassette. The absence of protein product was confirmed by western blot analysis. (J:135686)

Expression

In Mice Carrying this Mutation:	63 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r13b Mutation: 53 strains or lines available

References

• Original: J:135686 Hirashima M, et al., Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol. 2008 Apr 1;316(1):149-59
• All: 4 reference(s)