Gsk3b^tm2Jrw
Targeted Allele Detail

Summary

• Symbol: Gsk3b^tm2Jrw
• Name: glycogen synthase kinase 3 beta; targeted mutation 2, James R Woodgett
• MGI ID: MGI:3794785
• Synonyms: FLbeta, Gsk3beta^F, GSK3beta^fl, GSK-3beta Fl, GSK-3beta^FL, GSK3beta-floxed, Gsk3b^loxP, Gsk-3^F
• Gene: Gsk3b Location: Chr16:37909363-38066446 bp, + strand Genetic Position: Chr16, 26.54 cM, cytoband B4
• Alliance: Gsk3b^tm2Jrw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135659
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and an FRT site flanked neomycin resistance gene cassette was inserted. Flp-mediated recombination in ES cells removed the neo cassette. (J:135659, J:140395)

Expression

In Mice Carrying this Mutation:	3 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gsk3b^tm2Jrw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gsk3b Mutation: 113 strains or lines available

References

• Original: J:135659 Tanabe K, et al., Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS Biol. 2008 Feb;6(2):e37
• All: 72 reference(s)