Akt1^Gt1Pnt
Gene trapped Allele Detail

Summary

• Symbol: Akt1^Gt1Pnt
• Name: thymoma viral proto-oncogene 1; gene trap 1, Philip N Tsichlis
• MGI ID: MGI:3794786
• Synonyms: Akt1^-
• Gene: Akt1 Location: Chr12:112620260-112641266 bp, - strand Genetic Position: Chr12, 61.2 cM, cytoband F1-F2
• Alliance: Akt1^Gt1Pnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135903
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: A retrovirus vector integrated 3 bp upstream of the initiation methionine codon. The absence of protein product was confirmed by western blot analysis on mammary tissue extracts. (J:135903)

Tumor Data

List all tumor models in MMHCdb carrying Akt1^Gt1Pnt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt1 Mutation: 34 strains or lines available

References

• Original: J:135903 Mao C, et al., Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. J Immunol. 2007 May 1;178(9):5443-53
• All: 10 reference(s)