Scn10a^Psm
Chemically induced Allele Detail

Summary

• Symbol: Scn10a^Psm
• Name: sodium channel, voltage-gated, type X, alpha; possum
• MGI ID: MGI:3794859
• Synonyms: Nav1.8^Possum, Scn10a^m1Btlr
• Gene: Scn10a Location: Chr9:119437522-119548388 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband distal
• Alliance: Scn10a^Psm page

Scn10a^Psm/Scn10a^Psm mice display inducible immobility

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An A-to-G transition at nucleotide position 2403 of the gene (Genbank Accession NM_009134) results in replacement of threonine by alanine at amino acid position 790 of the Nav1.8 protein. This mutation produces a dominant hypermorph. (J:180381)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn10a Mutation: 102 strains or lines available

References

• Original: J:180381 Blasius AL, et al., Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19413-8
• All: 2 reference(s)