Nras^tm1Mok
Targeted Allele Detail

Summary

• Symbol: Nras^tm1Mok
• Name: neuroblastoma ras oncogene; targeted mutation 1, Moyota Katsuki
• MGI ID: MGI:3794957
• Synonyms: N-ras^-
• Gene: Nras Location: Chr3:102965643-102975230 bp, + strand Genetic Position: Chr3, 45.25 cM
• Alliance: Nras^tm1Mok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135610
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on E11.5 embryo extracts. (J:135610)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Nras Mutation: 44 strains or lines available

References

• Original: J:135610 Nakamura K, et al., Partial functional overlap of the three ras genes in mouse embryonic development. Oncogene. 2008 May 8;27(21):2961-8
• All: 2 reference(s)